Here are a few routes with countries/regions that have not been visited recently/frequently/ever
1. Houston, TX, USA -> Cartagena, Columbia
2. Bogota, Columbia
3. Bogota, Columbia -> San Jose, Costa Rica
4. San Jose, Costa Rica -> Kathmandu, Nepal
5. Kathmandu, Nepal -> Irkutsk, Russia
6. Novosibirsk, Russia
7. Novosibirsk, Russia -> Prague, Czech Republic
8. Prague, Czech Republic -> Helsinki, Finland
9. Helsinki, Finland -> Dublin, Ireland
10. Dublin, Ireland -> Monrovia, Liberia
11. Monrovia, Liberia
12. Monrovia, Liberia -> Orlando, FL, USA
1. New York, NY, USA -> Heraklion, Greece
2. Athens, Greece
3. Athens, Greece -> Kiev, Ukraine
4. Kiev, Ukraine -> Copenhagen, Denmark
5. Copenhagen, Denmark -> Mbabane, Swaziland
6. Mbabane, Swaziland
7. Mbabane, Swaziland -> Thimphu, Bhutan
8. Thimphu, Bhutan -> Seoul, South Korea
9. Seoul, South Korea -> Petropavlovsk-Kamchatskiy, Russia
10. Petropavlovsk-Kamchatskiy, Russia -> Manila, Philippines
11. Manila, Philippines -> Suva, Fiji
12. Suva, Fiji -> Phoenix, AZ, USA