There is no reason for the race to start on the east coast unless they are either going to Europe or connecting through Europe, as LA is such a convenience for production. With the Start Line potentially being MAJOR spoilers, it wouldn't make sense to fly to a first destination that is heavily populated, as we'd end up having the whole first leg spoiled by lots of people watching. I am almost certain that we are heading to Africa (a remote location somewhere), especially considering the early flights out of NYC to London as a connection. South Africa is a great contender, but I'm thinking they might take the race back to Victoria Falls for the first destination, where the magic started!