In relation to the recent news, I thought I would create a Family Edition-style route that touches the States not (currently) being affected by the outbreak. Let's get controversial.
STARTING LINE: National Capitol Columns at the National Arboretum in Washington, D.C.
Leg 1 (Washington, D.C. -> Virginia) | self-drive to Chesapeake Bay region
*Deep Creek Lock Park boat lockmastering Roadblock
Pit Stop: Dismal Swamp Canal Trail (skateboarding to a certain point)
Leg 2 (Virginia -> Kentucky) | flight to Louisville
*Churchill Downs human steeplechasing on a muddy course
*Kentucky Speedway "installing racecar stickers in a certain tesselation" Roadblock
Pit Stop: Kentucky Speedway (driving the racecar through a maze in the right order to get to the mat)
Leg 3 (Kentucky -> Minnesota) | flight from Cincinnati/Northern KY Int'l Airport to Minneapolis
*FAST FORWARD: 20 minutes just standing in Orfield Laboratories' anechoic chamber
*Spoonbridge and Cherry
*Walker Art Center "Internet Cat Video Festival" + animal shelter collaboration Roadblock
*Tandem biking across Stone Bridge Arch
*Hideaway Dinkytown for hookah glassblowing, one side of Detour
Pit Stop: Turnblad Mansion at American Swedish Institute
Leg 4 (Minnesota) | self-drive to Duluth
*Bakken Museum electricity experiment route info
*Aerial Lift Bridge never-before-done heights Roadblock
Pit Stop: Glensheen Estate facing Lake Superior
Leg 5 (Minnesota -> South Dakota -> Wyoming) | flight to Rapid City, visiting the Badlands
*Mount Rushmore drive-through
Pit Stop: Thunder Basin National Grassland (driving to a certain point, potentially lost)
Leg 6 (Wyoming) | self-drive out of prairie to Yellowstone National Park, possible double-episode Leg
*Road-trip themed tasks while driving a camper van
Pit Stop: Old Faithful Geyser
Leg 7 (Wyoming -> Montana -> Missouri -> Arkansas) | flight to Springfield
Pit Stop: Christ of the Ozarks in Eureka Springs
Leg 8 (Arkansas) | self-drive to Fayetteville, college-themed Leg
Pit Stop: Bud Walton Arena on University of Arkansas
Leg 9 (Arkansas -> Louisiana) | flight to New Orleans
Pit Stop: Oak Alley Plantation
Leg 10 (Louisiana -> New Mexico) | self-drive to Albuquerque, rural and historic connotations
Pit Stop: San Estevan del Rey Mission Church in Acoma Pueblo
Leg 11 (New Mexico -> Colorado) | flight to Denver
*Royal Gorge Bridge bungee jumping
*Air Force Academy in Colorado Springs
FINISH LINE: Garden of the Gods in Colorado Springs